HIV+ Heart Transplant; Small Watchman Leaks Risky; Breakthrough COVID and High BP

HIV+ Heart Transplant; Small Watchman Leaks Risky; Breakthrough COVID and High BP

July 27, 2022 0 By Jennifer Walker

The first heart transplant has been performed where both recipient and donor were HIV-positive, Montefiore Health System says.

Experiments show that cellular rejection after heart transplantation can be attributed to donor macrophages. Interference with macrophage signaling has potential to extend allograft survival. (Circulation)

Women in particular saw greater reductions in cardiovascular disease (CVD) risk with higher potassium intake, according a cohort study. (European Heart Journal)

Regarding lifestyle counseling for adults without CVD risk factors, the U.S. Preventive Services Task Force is sticking with its C grade recommendation that clinicians decide together with their patients.

Background cardiovascular therapy did not change the efficacy and safety of dapagliflozin (Farxiga) in patients with type 2 diabetes. (JAMA Cardiology)

In the phase IIa SEISMiC trial, istaroxime showed some blood pressure-lowering and echocardiographic benefits in pre-cardiogenic shock related to acute decompensated heart failure. (European Journal of Heart Failure)

Adherence to oral anticoagulation was significantly better among high-risk people diagnosed with nonvalvular atrial fibrillation (Afib) in the outpatient setting instead of hospitals or emergency departments. (Journal of the American Heart Association)

Postoperative Afib after noncardiac surgery was associated with no better or worse rates of stroke and cardiovascular death compared with Afib occurring outside the surgical setting. (Annals of Internal Medicine)

One year after Watchman left atrial appendage closure, any remaining small peridevice leaks were linked to increased thromboembolic risk driven by an uptick in nondisabling strokes within 5 years. (Journal of the American College of Cardiology)

EXCEL data suggest coronary artery bypass grafting surgery to be the cost-effective treatment for left main disease. This is not supported by other trials of percutaneous coronary intervention, however. (Circulation: Cardiovascular Interventions)

Biotronik announces FDA approval of the Pulsar-18 T3 stent system for treatment of the superficial femoral or proximal popliteal arteries. The tri-axial device comes in a 4-French size and features an ergonomic handle.

iRhythm Technologies announced FDA 510(k) clearance for the smartwatch software system ZEUS and the Zio Watch, an Afib-detecting wearable developed in partnership with Verily.

Stroke survivors tended to have worse blood pressure control compared with those with no history of stroke, according to a global study. (The Lancet Global Health)

A proposed approach to identifying late-presenting stroke patients who are good candidates for endovascular therapy without perfusion weighted imaging. (Stroke)

Flu vaccines were associated with better cardiovascular outcomes even among people with established heart disease, meta-analysis finds. (European Journal of Preventive Cardiology)

In cases of breakthrough SARS-CoV-2 infection among those fully vaccinated and boosted, hypertension was associated with more severe COVID-19 illness. (Hypertension)

Preclinical research finds the spike protein from SARS-CoV-2 causes heart muscle damage by activating the natural immune response in cells, the American Heart Association announced.

How many families of people with atherosclerotic CVD experience financial hardship? Depends on how that financial burden is defined. (JAMA Health Forum)

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    Nicole Lou is a reporter for MedPage Today, where she covers cardiology news and other developments in medicine. Follow