Snoring & Liver Disease; Remicade’s COVID Woes; Delays in Liver Cancer TreatmentAugust 5, 2022
What’s the link between snoring and fatty liver disease? (Journal of Clinical Endocrinology & Metabolism)
An appeals court sided with AbbVie, saying the company’s 132 patents related to its inflammatory bowel disease (IBD) drug adalimumab (Humira) didn’t unlawfully block competition. (Reuters)
A study of 8 million pregnancies found that women with IBD were more likely to experience poor maternal and fetal outcomes. (University of Missouri-Columbia, International Journal of Colorectal Disease)
Crohn’s disease patients who underwent ileocecal resection were less likely to experience recurrence if they started on a tumor necrosis factor (TNF) inhibitor within 4 weeks of surgery rather than later on. (Inflammatory Bowel Diseases)
IBD patients on infliximab (Remicade) were more likely to experience COVID reinfections and breakthrough cases during the Omicron wave compared to those on vedolizumab (Entyvio), researchers reported in Gut.
In a real-world study, Crohn’s disease patients on a TNF blocker were more likely to achieve clinical response at 3 months than those on ustekinumab (Stelara), an IL-12/23 inhibitor. (Inflammatory Bowel Diseases)
Racial minority groups with ulcerative colitis may not respond as well to golimumab (Simponi), an analysis of the Yale Open Data Access Project found. (Inflammatory Bowel Diseases)
For the first time, an oral phage combination therapy can precisely target gut bacteria linked with IBD while sparing beneficial microbes, researchers reported in Cell.
In a randomized, phase II gluten-challenge study in celiac disease, the investigational enzyme product latiglutenase (IMGX003) reduced symptom severity and intestinal mucosal damage. (Gastroenterology)
An extracellular vesicle-based surface protein assay has the potential to bolster current surveillance methods for early liver cancer detection, researchers argue in Hepatology.
Nearly one in seven liver cancer patients experience treatment delays, with Black individuals and those living in poverty disproportionately affected. (Clinical Gastroenterology and Hepatology)